Unfortunately, little is known about taurine’s neuroendocrine effects. But it is also a major ingredient in popular energy drinks, which thus constitute a major source of taurine supplementation. In addition, after density gradient centrifugation of rat brain homogenate, both cysteinesulphinate decarboxylase activity and taurine has been found to be enriched in the nerve ending fractions 4. Taurine is an amino acid found abundantly in brain, reti-na, heart, and reproductive organ cells, as well as in meat and seafood.
In this study, we show that taurine reduced the excitability of thalamocortical. In a number of studies, taurine has been reported to activate glycine receptors (Gly-Rs) at moderate concentrations (100 m), and to be a weak agonist at GABAA receptors (GABAA-Rs), which are usually activated at high concentrations (1 mm).
TAURINE EFFECTS NEUROTRANSMITTER FREE
Aminobutyric acid (GABA) is the main inhibitory neurotransmitter of the mammalian CNS. Taurine is one of the most abundant free amino acids in the brain.
There are also similarities in the distribution of both these amino-acids and in the localization of their synthesizing enzymes in different regions of the brain 4. Taurine is able to cross the blood-brain barrier and is linked to several physiological functions as a result of the way it interacts with the CNS. However, this effect is limited by the capacity to internalize the taurine into the brain under pathological conditions and the mechanism of taurine excretion by urine Citation 2. It has been suggested that taurine acts as a transmitter Curtis and Watkins 3 have evidence that among other amino-acids, taurine when applied iontophoretically to the vicinity of a neurone in the central nervous system exerts an inhibitory effect on the rate of firing and, furthermore, there is a structural resemblance between γ-aminobutyric acid (GABA) and taurine. APART from the dicarboxylic acids, taurine is the most abundant amino-acid in the nervous system 1, and yet very little is known about its function 2. We found that taurine was mostly devoid of effects and did not counteract the behavioral alterations induced in such animal models.
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